M.J. van der Laan, S. Rose (2017). Targeted Learning in Data Science: Causal Inference for Complex Longitudinal Studies. New York, Springer. 

M.J. van der Laan, S. Rose (2011). Targeted Learning: Causal Inference for Observational and Experimental Data. New York, Springer. 

[Book Summaries] []

*Trainee author    +Senior author

Journal Articles


S. Rose, S.L. Normand. Robust estimation for multiple unordered treatments: Evaluating drug-eluting coronary artery stents, revise & resubmit.

A. Shrestha*, S. Bergquist*, E. Montz, S. Rose+. Mental health risk adjustment with clinical categories and machine learning, revise & resubmit.

S. Rose. Robust machine learning variable importance analyses of medical conditions for health care spending, revise & resubmit.

R. Gourevitch, S. Rose, S. Crockett, M. Morris, D. Carrell, J. Greer, R. Pai, R. Schoen, A. Mehrotra. Variation in pathologist classification of colorectal adenomas and serrated polyps, revise & resubmit.

C. Lee, S. Haneuse, H.L. Wang, S. Rose, S. Spellman, M. Verneris, K. Hsu, K. Fleischhauer, S. Lee, R. Abdi. Prediction of acute graft-versus-host disease following hematopoietic cell transplantation, under review.

S. Crockett, R. Gourevitch, M. Morris, D. Carrell, S. Rose, J. Greer, R. Schoen, A. Mehrotra. Serrated polyp detection is related to training and colonoscopy volume: Results from a multicenter US study, under review.

M. Barnett, Z. Song, A. Bitton, S. Rose, B. Landon. Gatekeeping and patterns of outpatient care in the post-health reform era, under review.


A.J. Rosellini*, F. Dussaillant, J. Zubizarreta, R. Kessler, S. Rose+ (2017). Predicting posttraumatic stress disorder following a natural disaster. Journal of Psychiatric Research. Advance online publication. doi:10.1016/j.jpsychires.2017.09.010. [Link]

F. Mateen, E. McKenzie, S. Rose+ (2017). Medical schools in fragile states: Implications for delivery of care. Health Services Research, in press.

A. Mehrotra, M. Morris, R. Gourevitch, D. Carrell, D. Leffler, S. Rose, J. Greer, S. Crockett, A. Baer, R. Schoen (2017). Physician characteristics associated with higher adenoma detection rate. Gastrointestinal Endoscopy. Advance online publication. doi:10.1016/j.gie.2017.08.023. [Link]

S. Bergquist*, G. Brooks, N. Keating, M.B. Landrum, S. Rose+ (2017). Classifying lung cancer severity with ensemble machine learning in health care claims data. Proceedings of Machine Learning Research, in press. [PDF] [MLHC 2017] []

A. Sinaiko, T. Layton, S. Rose, T. McGuire (2017). Implications of family risk pooling for individual health insurance markets. Health Services and Outcomes Research Methodology. Advance online publication. doi:10.1007/s10742-017-0170-3. [Link]

M. Barnett, Z. Song, S. Rose, A. Bitton, M. Chernew, B. Landon (2017). Insurance transitions and changes in physician and emergency department utilization: An observational study. Journal of General Internal Medicine. 32(10):1146-55. [Link]
   Editorial in JGIM by Dworsky

S. Rose, S. Bergquist*, T. Layton (2017). Computational health economics for identification of unprofitable health care enrollees. Biostatistics. Advance online publication. doi:10.1093/biostatistics/kxx012. [Link][Code]
   Harvard Medical School News: "Deep Dive"

D. Carrell, R. Schoen, D. Leffler, M. Morris, S. Rose, A. Baer, S. Crockett, R. Gourevitch, K. Dean, A. Mehrotra (2017). Challenges in adapting existing clinical natural language processing systems to multiple, diverse healthcare settings. Journal of the American Medical Informatics Association. 24(5):986-91. [Link

A. Mehrotra, H. Huskamp, J. Souza, L. Uscher-Pines, S. Rose, B. Landon, A. Jena, A. Busch (2017). Rapid growth in mental health telemedicine use among Medicare beneficiaries, wide variation across states. Health Affairs, 36(5):909-17. [Link]
   Harvard Medical School News: "Mental Health on the Line"
   Press coverage in Politico

Z. Song, S. Rose, M. Chernew, D. Gelb Safran (2017). Lower versus higher income populations in the Alternative Quality Contract: Improved quality and similar spending. Health Affairs, 36(1):74-82. [Link]
   Harvard Medical School News: "Raising Quality"
   Press coverage in The Boston Globe, WBUR, AJMC

M. Schuler*, S. Rose+ (2017). Targeted maximum likelihood estimation for causal inference in observational studies. American Journal of Epidemiology, 185(1):65-73. [Link]

J. Spertus, S.L. Normand, R. Wolf, M. Cioffi, A. Lovett, S. Rose+ (2016). Assessing hospital performance after percutaneous coronary intervention using big data. Circulation: Cardiovascular Quality and Outcomes, 9:659-69. [PDF]

S. Rose (2016). A machine learning framework for plan payment risk adjustment. Health Services Research, 51(6):2358-74 . [Link]
   Harvard Medical School News: "Deep Dive"
   Discussed by AHE Blog

E. Montz, T. Layton, A. Busch, R. Ellis, S. Rose, T. McGuire (2016). Risk adjustment simulation: Plans may have incentives to distort mental health and substance use coverage. Health Affairs, 35(6):1022-8. [PDF]
   Harvard Medical School News: "Managing the Marketplace"
   Press briefing video: Behavioral Health, National Press Club (0:04:21-0:11:33)
   Press coverage in AJMC

S. Rose, A. Zaslavsky, J.M. McWilliams (2016). Variation in accountable care organization spending and sensitivity to risk adjustment: Implications for benchmarking. Health Affairs, 35(3):440-8. [Link]
   Featured in official letter to CMS signed by 22 health organizations, AMGA letter
   Discussed by Health Affairs BlogHealthExec, CHSR, The Source

A. Mirelman*, S. Rose, J. Khan, S. Ahmed, D. Peters, L. Niessen, A. Trujillo (2016). The relationship between noncommunicable disease occurrence and poverty: Evidence from demographic surveillance in Matlab, Bangladesh. Health Policy and Planning, 31(6):785-92. [PDF]

S. Rose (2015). Targeted learning for pre-analysis plans in public health and health policy research. Observational Studies, 1:294-306. [PDF]

H. Abdul-Baki, R. Schoen, K. Dean, S. Rose, D. Leffler, E. Kuganeswaran, M. Morris, D. Carrell, A. Mehrotra (2015). Public Reporting of Colonoscopy Quality is Associated with an Increase in Endoscopist Adenoma Detection Rate. Gastrointestinal Endoscopy, 82(4):676-82. [Link]
   "Editor's Choice" article
   Editorial in GIE by Lieberman & Mascarenhas
   Evaluated by Faculty of 1000

F. Marcondes, K. Dean, R. Schoen, D. Leffler, S. Rose, M. Morris, A. Mehrotra (2015). The Impact of Exclusion Criteria on a Physician’s Adenoma Detection Rate. Gastrointestinal Endoscopy, 82(4):668-75. [Link]
   Video Interview with GIE
   Editorial in GIE by Lieberman & Mascarenhas

S. Rose, J. Shi, T. McGuire, S.L. Normand (2015). Matching and imputation methods for risk adjustment in the Health Insurance Marketplaces. Statistics in Biosciences. Advance online publication. doi:10.1007/s12561-015-9135-7. [Link]

R. Kessler, C. Warner, C. Ivany, M. Petukhova, S. Rose, E. Bromet, M. Brown, T. Cai, L. Colpe, K. Cox, C. Fullerton, S. Gilman, M. Gruber, S. Heeringa, L. Lewandowski-Romps, J. Li, A. Millikan-Bell, J. Naifeh, M. Nock, A. Rosellini, N. Sampson, M. Schoenbaum, M. Stein, S. Wessely, A. Zaslavsky, R. Ursano (2015). Predicting suicides after psychiatric hospitalization in US Army soldiers. JAMA Psychiatry, 72(1):49-57. [Link]
   Harvard Medical School News
   Press coverage in The New York Times, USA Today, US News, Los Angeles Times

A. Street, S. Gilman, A. Rosellini, M. Stein, E. Bromet, K. Cox, L. Colpe, C. Fullerton, M. Gruber, S. Heeringa, L. Lewandowski-Romps, R. Little, J. Naifeh, M. Nock, N. Sampson, M. Schoenbaum, R. Ursano, A. Zaslavsky, R. Kessler, Army STARRS Collaborators (2015). Understanding the elevated suicide risk of female soldiers during deployments. Psychol Med, 45(4):717-26. [Link]

Z. Song, S. Rose, D. Safran, B. Landon, M. Day, M. Chernew (2014). Changes in health care spending and quality 4 years into global payment. N Engl J Med, 371(18): 1704-14. [Link]
   Video Summary
   Harvard Medical School News: "Four Years In..." and "Health Reform Progress"
   Press coverage in The New York TimesUS NewsThe Boston Globe, AJMCModern Healthcare
   Editorial in NEJM by L.P. Casalino

R. Kessler, S. Rose, K. Koenen, E. Karam, P. Stang, D. Stein, S. Heeringa, E. Hill, I. Liberzon, K. McLaughlin, S. McLean, B. Pennell, M. Petukhova, A. Rossellini, A. Ruscio, V. Shahly, A. Shalev, D. Silove, M. van Ommeren, A. Zaslavsky, M. Angermeyer, E. Bromet, J. Caldas de Almedia, G. de Girolamo, P. de Jonge, K. Demyttenaere, S. Forescu, O. Gureje, J. Haro, H. Hinkov, N. Kawakami, V. Kovess-Masfety, S. Lee, M. Medina-Mora, S. Murphy, F. Navarro-Mateu, M. Piazza, J. Posada-Villa, K. Scott, Y. Torres, M. Viana (2014). How well can post-trauamtic stress disorder be predicted from pre-trauma risk factors? An exploratory study in the WHO World Mental Health Surveys. World Psychiatry, 13(3): 265-74. [PDF]

S. Rose, M.J. van der Laan (2014). Rose and van der Laan respond to "Some advantages of RERI."  Am J Epidemiol, 179(6)672-3. [PDF]

S. Rose, M.J. van der Laan (2014). A double robust approach to causal effects in case-control studies.  Am J Epidemiol, 179(6):663-9. [PDF]

L. Lewandowski-Romps, C. Peterson, P. Berglund, S. Collins, K. Cox, K. Hauret, B. Jones, R. Kessler, C. Mitchell, N. Park, M. Schoenbaum, M. Stein, R. Ursano, S. Heeringa, Army STARRS Collaborators (2014). Risk factors for accident death in the U.S. Army, 2004-2009. Am J Prev Med, 47(6):745-53. [Link]

H. Wang, Z. Zhang, S. Rose, M.J. van der Laan (2014). A novel targeted learning method for quantitative trait loci mapping. Genetics, 198(4): 1369-76. [PDF]
   "Highlights" article

K. Wardnaar, H. van Loo, T. Cai, M. Fava, M. Gruber, J. Li, P. de Jonge, A. Nierenberg, M. Petukhova, S. Rose, N. Sampson, R. Schoevers, M. Wilcox, J. Alonso, E. Bromet, M. Bunting, S. Florescu, A. Fukao, O. Gureje, C. Hu, Y. Huang, A. Karam, D. Levinson, M. Medina Mora, J. Posada-Villa, K. Scott, N. Taib, M. Viana, M. Xavier, Z. Zarkov, R. Kessler (2014). The effects of comorbidity in defining major depression subtypes associated with long-term course and severity. Psychological Medicine, 44(15):3289-302. [Link]

H. van Loo, T. Cai, M. Gruber, J. Li, P. de Jonge, M. Petukhova, S. Rose, N. Sampson, R. Schoevers, K. Wardenaar, M. Wilcox, A. Al-Hamzawi, L. Andrade, E. Bromet, B. Bunting, J. Fayyad, S. Florescu, O. Gureje, C. Hu, Y. Huang, D. Levinson, M. Medina-More, Y. Nakane, J. Posada-Villa, K. Scott, M. Xavier, Z. Zarkov, R. Kessler (2014). Major depressive disorder subtypes to predict long-term course. Depression and Anxiety, 31(9):765-77. [Link]

S. Rose (2013). Mortality risk score prediction in an elderly population using machine learning. Am J Epidemiol, 177(5):443-452. [PDF
   "Editor's Choice" article
   Press coverage in Slate

H. Wang, S. Rose, M.J. van der Laan (2011). Finding quantitative trait loci genes with collaborative targeted maximum likelihood learning. Stat Probabil Lett, 81(7):792–6. [PDF
   Featured in issue editorial

S. Rose, J. Snowden, K.M. Mortimer (2011). Rose et al. respond to “G-computation and standardization in epidemiology.” Am J Epidemiol, 173(7):743–4. [PDF]

J. Snowden, S. Rose, K.M. Mortimer (2011). Implementation of G-Computation on a simulated data set: demonstration of a causal inference technique. Am J Epidemiol, 173(7):731–8. [PDF]   
   Evaluated by Faculty of 1000

S. Rose, M.J. van der Laan (2011). A targeted maximum likelihood estimator for two-stage designs. Int J Biostat, 7(1):17. [PDF
   ASA Statistics in Epidemiology Graduate Student Travel Award

H. Li, H. Grigoryan, W. Funk, S. Lu, S. Rose, E.R. Williams, S.M. Rappaport (2011). Profiling Cys34 adducts of human serum albumin by fixed-step selected reaction monitoring. Mol Cell Proteomics, 10(3):M110.004606. [PDF]

K. Huen, L. Barcellos, K. Beckman, S. Rose, B. Eskenazi, N. Holland (2011). Effects of PON polymorphisms and haplotypes on molecular phenotype in Mexican-American mothers and children. Environ Mol Mutag, 52(2):105-16. [PDF]
   "Editor's Choice" article; featured on issue cover
   EMS Award

S. Rose, M. J. van der Laan (2009). Why match? Investigating matched case-control study designs with causal effect estimation. Int J Biostat, 5(1):1. [PDF]

S. Rose, M.J. van der Laan (2008). Simple optimal weighting of cases and controls in case-control studies. Int J Biostat, 4(1):19. [PDF]

S. Cokus, S. Rose, D. Haynor, N. Gronbech-Jensen, M. Pellegrini (2006). Modeling the network of cell cycle transcription factors in the yeast Saccharomyces cerevisiaeBMC Bioinformatics, 7:381. [PDF]
   Highly accessed

V. Berger, S. Rose (2004). Ensuring the comparability of comparison groups: is randomization enough? Control Clin Trials, 25(5):515–24. [PDF]
   Discussed in Science News

Book Chapters

R. Ellis, B. Martins, S. Rose (2017). Estimation and implementation of risk adjustment models for health plan payments. In T. McGuire, R. van Kleef, eds. Risk Adjustment, Risk Sharing and Premium Regulation in Health Insurance Markets: Theory and Practice. Elsevier.

L. Kunz, S. Rose, D. Spiegelman, S.L. Normand (2017). An overview of approaches for comparative effectiveness research. In C. Gatsonis, S. Morton, eds. Methods in Comparative Effectiveness Research. Boca Raton: Chapman and Hall/CRC.

S. Rose (2016). Targeted learning for variable importance. In P. Bühlmann, M. Kane, P. Drineas, M. van der Laan, eds. Handbook of Big Data. Boca Raton: Chapman and Hall/CRC.


C. Rudin, D. Dunson, R. Irizarry, H. Ji, E. Laber, J. Leek, T. McCormick, S. Rose, C. Schafer, M. van der Laan, L. Wasserman, L. Xue; A Working Group of the American Statistical Association (2014). Discovery with Data: Leveraging Statistics and Computer Science to Transform Science and Society. [PDF]
   Press Release
   Amstat News Article


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